Dendritic Cell Activation

In the third step, some of the macrophages that have returned from the battle with the tumor cells will be saturated with the broken pieces of cancer cells. These macrophages will be carefully selected and sorted, to be set aside and incubated in a special section of the BioPACK™. Inside these incubating chambers, some of these macrophages will morph, like a caterpillars becoming butterflies inside a cocoon, into a crucially important cell – the Dendritic Cell.

The Dendritic Cell plays a crucial role in helping the body make a vaccine by telling a patient's body what to attack, with specially marked proteins, called antibodies. One of the reasons cancers are so deadly is because they somehow manage to short-circuit this vaccine producing step. In the incubation chamber, safe from the influence of cancer-released cytokines, the Reveal BioPACK™ shepherds Dendritic Cells into existence, and then releases them back into the body at the right time.

Once back in the body, these powerful cells will make their way to lymph nodes. There, in the lymph nodes, Dendritic Cells begin a complicated chemical conversation with other immunocytes, primarily T-cells, to identify what vaccine the body can raise against the cancer. This is called a Dendritic Cell Response, and it is essential to the body's vaccine-making efforts. During the conversation, the Dendritic Cells will try to match the proteins that they consumed during their fight with the tumor cells, to T-cells that know how to recognize those same proteins. When a T-cell is found that recognizes the tumor, that T-cell will be helped to recruit other cells that will make large quantities of antibody – the vaccine. The production of these antibodies will rise, and be dispersed throughout the body.

Once the production of antibodies start, the antibodies will eventually reach the tumor, and mark it, so that various killer immunocytes will hone in on the cancer and decimate it, with laser-like efficiency. Reveal scientists speculate that most spontaneous remissions are most likely the natural result of the body manufacturing a vaccine against the tumor. With the BioPACK™, Reveal intends to help as many patients as possible create their own vaccine. Thus, the patient's own immune system will vaccinate themselves against their cancer.