Apheresis and immunocyte activation are medical procedures that kill cancer cells without damaging healthy cells. Reveal Therapies is developing a small portable device that will perform both procedures while patients are working, playing, sleeping, or even exercising. The purpose of this website is to describe apheresis, immunocyte activation, and the Reveal BioPACK
The problem, in a nutshell
Unless a cure is found, solid tumor cancers will kill one out of seven
people alive today. The traditional treatments for solid tumor cancers
--surgery, radiation, and chemotherapy-- are painful, dangerous,
expensive, and disfiguring. Furthermore, cancer returns in well over
half of all patients treated with these methods.
At Reveal Therapies, we think we can do better. Much better!
Our solution, in a nutshell
Instead of using surgery, radiation, and chemotherapy, Reveal is
designing a small wearable, battery-operated device that will help the
immune system to find and destroy cancer cells. Blood will be pumped
through the Reveal BioPACK™, treated by our patented "Technologies for
Receptor Activation of Cells – Especially Macrophages
techniques, and returned to the patient. This treatment will go on for
six to twenty-four weeks, and it will change cancer from a death
sentence to a manageable, chronic condition for more than half of the
patients treated. Some of those patients will see the cancer disappear
"TRAC-EM™" is a combination of patented procedures that are
implemented at the microfludic level. Metaphorically, these
technologies do two important things. At the right times, "TRAC-EM™"
gently "push" immunocytes (Macrophages) towards a better response to a
cancer. And at other times, "TRAC-EM™" gently "pull" immunocytes
(Macrophages) towards a better response to cancer. "TRAC-EM™" is
implemented in the BioPACK™ by using proven and well known techniques
from apheresis and immunocyte activation.
How apheresis reveals hidden cancer cells
The immune system produces immunocytes (white blood cells) that find
and kill germs. There are also immunocytes that can find and "eat"
cancerous cells. Immunocytes are guided by cytokines, chemical signals
produced by cells.
Infected or damaged cells --including some cancer cells-- produce "Eat
me!" cytokines that tell immunocytes to destroy them; healthy
self-cells produce "Don't eat me!" cytokines. Some solid cancers hide
from the immune system by producing phony "Don't eat me!" cytokines.
These phony cytokines are called cloaking cytokines.
The Reveal BioPACK™ will use apheresis to remove cloaking cytokines
from the patient's blood, and then return the blood to the patient.
With the cloaking cytokines removed, immunocytes will be able to find
cancer cells that had been hiding.
How immunocyte activation kills cancer cells
Immunocytes come into the world like babies, full of potential, but
not knowing much. They live for a short while, from a couple of days
to a couple of months. During that brief span, they need to learn how
to tell the difference between the body's own cells and germs, and
between healthy cells and cancerous cells. Immunocyte activation
speeds up the learning process, enabling more immunocytes to find and
kill cancer cells. The immunocytes to be activated by the Reveal
Device are macrophages and dendritic cells.
When you have the flu, your aches, pains, and fever are caused by
immunocytes tracking down and killing flu viruses, and the cells
infected by them. Apheresis and immunocyte activation will cause
flu-like symptoms as immunocytes track down and kill cancer cells. The
flu-like symptoms will subside as the cancer cells disappear. Reveal's
BioPACK™ solution operates in direct contrast to chemotherapy and
radiation therapy, which are outright deadly poisons! And no matter
how sophisticated the delivery system of these poisons, everyone knows
some of the side-effects because they are so destructive. Reveal's
BioPACK™ is not destructive to anything, but tumors.